Reactivity of the isolated perfused rat tail vascular bed
نویسندگان
چکیده
منابع مشابه
Reactivity of the isolated perfused rat tail vascular bed.
Isolated segments of the perfused rat tail artery display a high basal tone when compared to other isolated arteries such as the mesenteric and are suitable for the assay of vasopressor agents. However, the perfusion of this artery in the entire tail has not yet been used for functional studies. The main purpose of the present study was to identify some aspects of the vascular reactivity of the...
متن کاملEffects of mercury on the isolated perfused rat tail vascular bed are endothelium-dependent.
The effects of mercury on vascular smooth muscle results in vasoconstriction, but the mechanism of this action is not elucidated yet. To investigate this issue we examined the effects of HgCl(2) in the isolated rat tail vascular bed. The tail artery was dissected, cannulated, and perfused at a constant flow (2.5 ml/min) with Krebs solution plus EDTA 0.03 mM at 36 degrees C. After equilibration ...
متن کاملInhibition of Ras-GTPase improves diabetes-induced abnormal vascular reactivity in the rat perfused mesenteric vascular bed.
OBJECTIVE The signalling mechanisms involved in regulating altered vascular reactivity in diabetes are not fully understood. The aim of this study was to investigate the role of Ras-GTPase in the development of abnormal vascular reactivity in diabetes. MATERIALS AND METHODS We investigated the ability of chronic administration of FPTIII (1.5 mg/kg), an inhibitor of Ras-GTPase, to modulate the...
متن کاملSEQUESTRATION OF LEUKOCYTES BY THE ISOLATED PERFUSED RAT LUNG
The sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. The passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. Leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematop...
متن کاملVascular reactivity of perfused vascular bed in spontaneously hypertensive and normotensive rats.
1 Hypertensive and normotensive rats of the same age group were isolated from an inbred colony of spontaneously hypertensive rats. 2 The perfused hindquarter and mesenteric artery preparations obtained from hypertensive and normotensive rats exhibited an increased reactivity to noradrenaline (NA) and angiotensin II. 3 Dose-response curves to NA obtained from hypertensive and normotensive rats e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 1997
ISSN: 0100-879X
DOI: 10.1590/s0100-879x1997000700012